Ndị nchọpụta achọpụtala na isi metabolite nke THC ka dị ike dabere na data sitere na ụdị òké. Nchọpụta nyocha ọhụrụ na-egosi na isi THC metabolite na-anọ n'ime mmamịrị na ọbara nwere ike ka na-arụ ọrụ yana dị ka THC, ma ọ bụrụ na ọ bụghị karịa. Nchọpụta ọhụrụ a na-ewelite ajụjụ karịa ka ọ na-aza. Dị ka otu nnyocha e bipụtara na nso nso a na Journal of Pharmacology and Experimental Therapeutics, psychoactive metabolite nke THC, 11-hydroxy-THC (11-OH-THC), nwere nha ma ọ bụ ukwuu psychoactive ike karịa THC (Delta-9 THC).
Ọmụmụ ihe a, akpọrọ "Mbaụbiga mmanya ókè nke 11-Hydroxy-Delta-9-THC (11-OH-THC) metụtara Delta-9-THC," na-egosi ka metabolites THC na-ejigide ọrụ. A maara nke ọma na THC na-agbaji ma na-emepụta ogige ọhụrụ na-akpali akpali mgbe ọ na-emepụta ihe na-eme ka ọ na-eme ihe n'ime ahụ mmadụ. "N'ime ọmụmụ ihe a, anyị kpebisiri ike na isi metabolite nke THC, 11-OH-THC, na-egosipụta ọrụ nha ma ọ bụ karịa THC na ụdị ọrụ cannabinoid nke òké mgbe a na-elekọta ya, ọbụna na-atụle ọdịiche dị na ụzọ nchịkwa, mmekọahụ, pharmacokinetics, na pharmacodynamics," ka ọmụmụ ahụ na-ekwu. "Ihe data ndị a na-enye nghọta dị oke mkpa banyere ọrụ ndu nke THC metabolites, na-agwa nyocha cannabinoid n'ọdịnihu, ma gosipụta otú oriri THC na metabolism si emetụta iji cannabis mmadụ."
Ndị otu sitere na Saskatchewan, Canada mere nchọpụta a, gụnyere Ayat Zagzoog, Kenzie Halter, Alayna M. Jones, Nicole Bannatyne, Joshua Cline, Alexis Wilcox, Anna-Maria Smolyakova, na Robert B. Laprairie. N'ime nnwale ahụ, ndị nchọpụta gbara ụmụ oke 11-hydroxy-THC wee hụ ma mụọ mmetụta nke metabolite THC a ma e jiri ya tụnyere ogige nne na nna ya, Delta-9 THC.
Ndị nchọpụta ahụ gara n'ihu kwuo, sị: "Ihe data ndị a na-egosi na n'ime ule ọdụ-flick maka nghọta mgbu, ọrụ nke 11-OH-THC bụ 153% nke THC, na na nyocha catalepsy, ọrụ nke 11-OH-THC bụ 78% nke THC. Ya mere, ọbụna na-atụle pharmacokinetic dị iche iche, 11-OH na-arụ ọrụ dị ukwuu karịa ihe dị iche iche nke pharmacokinetic, 11-OH na-arụ ọrụ karịa ihe mgbagwoju anya. THC."
Yabụ, ọmụmụ ihe ahụ na-atụ aro na THC metabolite 11-OH-THC nwere ike rụọ ọrụ dị mkpa na ọrụ ndu nke cannabis. Ịghọta ọrụ ya mgbe a na-elekọta ya ozugbo ga-enyere aka ịkọwa anụmanụ na ọmụmụ mmadụ n'ọdịnihu. Nkwupụta ahụ kwuru na 11-OH-THC bụ otu n'ime metabolites abụọ a na-eme ka emechara cannabis, nke ọzọ bụ 11-nor-9-carboxy-THC, nke na-abụghị psychoactive mana ọ nwere ike ịdịgide na ọbara ma ọ bụ mmamịrị ogologo oge.
Dabere na Centlọ Ọrụ Maka Nchịkwa na Mgbochi Ọrịa US (CDC), na mbido 1980s, ule mmamịrị bụ isi 11-nor-delta-9-THC-9-carboxylic acid (9-carboxy-THC), metabolite nke Delta-9-THC, nke bụ isi ihe na-arụ ọrụ na cannabis.
Nkwupụta ahụ na-egosi na n'agbanyeghị na ịṅụ sịga na-arụpụta mmetụta ngwa ngwa karịa iri ihe oriri cannabis, ọnụ ọgụgụ 11-OH-THC na-emepụta site na ingestion karịrị nke ise siga cannabis. Nkwupụta ahụ na-atụ aro na nke a bụ otu ihe kpatara nri ndị nwere cannabis nwere ike isi bụrụ ndị na-akpa ike ma na-akpata ọgba aghara maka ndị na-akwadoghị.
THC metabolites na nnwale ọgwụ
Ihe akaebe na-egosi na cannabis na-emetụta ndị ọrụ dị iche iche dabere na ụzọ nchịkwa. Nnyocha ọmụmụ 2021 e bipụtara na akwụkwọ akụkọ Permanent gosiri na mmetụta nke iri ihe oriri cannabis karịrị nke ị smokingụ sịga n'ihi metabolism nke 11-OH-THC.
"The bioavailability nke THC site vaporization bụ 10% ka 35%," ndị nchọpụta dere. "Mgbe mmịkọ gasịrị, THC na-abanye na imeju, ebe ọtụtụ n'ime ya na-ekpochapụ ma ọ bụ metabolized n'ime 11-OH-THC ma ọ bụ 11-COOH-THC, na THC fọdụrụnụ na metabolites ya na-abanye n'ọbara. Site n'ọnụ ọnụ, bioavailability nke THC bụ nanị 4% ruo 12%. ọkara ndụ THC plasma na ndị ọrụ oge ụfọdụ bụ ụbọchị 1 ruo 3, ebe ndị ọrụ na-adịghị ala ala, ọ nwere ike ịdị ogologo ụbọchị 5 ruo 13.
Nnyocha na-egosi na ogologo oge mgbe mmetụta psychoactive nke cannabis kwụsịrị, THC metabolites dị ka 11-OH-THC nwere ike ịnọgide na ọbara na mmamịrị ruo ogologo oge. Nke a na-ebute ihe ịma aka maka usoro ọkọlọtọ iji nwalee ma ndị ọkwọ ụgbọ ala na ndị na-eme egwuregwu enweghị nsogbu n'ihi iji cannabis. Dịka ọmụmaatụ, ndị nyocha Australia na-anwa ịchọpụta oge nke cannabis nwere ike imebi arụmọrụ ịnya ụgbọ ala. N'otu oge, Thomas R. Arkell, Danielle McCartney na Iain S. McGregor sitere na Lambert Initiative na Mahadum Sydney mụrụ mmetụta cannabis na ikike ịnya ụgbọ ala. Ndị otu ahụ kpebiri na cannabis na-emebi ikike ịnya ụgbọ ala ruo ọtụtụ awa mgbe ị smokingụ sịga, mana mmebi ndị a na-akwụsị tupu ekpochapụ metabolites THC na ọbara, na metabolites na-adịgide n'ime ahụ ruo izu ma ọ bụ ọnwa.
"Ndị ọrịa na-eji ngwaahịa nwere THC kwesịrị izere ịnya ụgbọ ala na ọrụ nchekwa ndị ọzọ (dịka, igwe na-arụ ọrụ), karịsịa n'oge ọgwụgwọ mbụ na ruo ọtụtụ awa mgbe ọgwụ ọ bụla gasịrị," ndị dere dere. Ọbụlagodi na ndị ọrịa anaghị eche na ọ nweghị nsogbu, ha ka nwere ike nwalee nke ọma maka THC. Ọzọkwa, a naghị ahapụ ndị ọrịa cannabis ọgwụ ugbu a na nnwale ọgwụ mkpanaka n'akụkụ okporo ụzọ yana mmachi iwu metụtara ya.
Nnyocha ọhụrụ a na 11-OH-THC na-egosi na ọ dị mkpa ka ọmụmụ ihe dịkwuo mkpa iji ghọta nke ọma ka metabolites THC si emetụta ahụ mmadụ. Naanị site na mbọ na-aga n'ihu, anyị nwere ike ikpughe ihe nzuzo nke ogige ndị a pụrụ iche.
Oge nzipu: Mar-21-2025